Zhang, Z;
Russell, LE;
Packer, AM;
Gauld, OM;
Hausser, M;
(2018)
Closed-loop all-optical interrogation of neural circuits in vivo.
Nature Methods
, 15
(12)
pp. 1037-1040.
10.1038/s41592-018-0183-z.
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Abstract
Understanding the causal relationship between neural activity and behavior requires the ability to perform rapid and targeted interventions in ongoing activity. Here we describe a closed-loop all-optical strategy for dynamically controlling neuronal activity patterns in awake mice. We rapidly tailored and delivered two-photon optogenetic stimulation based on online readout of activity using simultaneous two-photon imaging, thus enabling the manipulation of neural circuit activity ‘on the fly’ during behavior.
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