Weaver, NA;
Doeven, T;
Barkhof, F;
Biesbroek, JM;
Groeneveld, ON;
Kuijf, HJ;
Prins, ND;
... TRACE-VCI study group, .; + view all
(2019)
Cerebral amyloid burden is associated with white matter hyperintensity location in specific posterior white matter regions.
Neurobiology of Aging
10.1016/j.neurobiolaging.2019.08.001.
(In press).
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Abstract
White matter hyperintensities (WMHs) are a common manifestation of cerebral small vessel disease. WMHs are also frequently observed in patients with familial and sporadic Alzheimer's disease, often with a particular posterior predominance. Whether amyloid and tau pathologies are linked to WMH occurrence is still debated. We examined whether cerebral amyloid and tau burden, reflected in cerebrospinal fluid amyloid-beta 1-42 (Aβ-42) and phosphorylated tau (p-tau), are related to WMH location in a cohort of 517 memory clinic patients. Two lesion mapping techniques were performed: voxel-based analyses and region of interest-based linear regression. Voxelwise associations were found between lower Aβ-42 and parieto-occipital periventricular WMHs. Regression analyses demonstrated that lower Aβ-42 correlated with larger WMH volumes in the splenium of the corpus callosum and posterior thalamic radiation, also after controlling for markers of vascular disease. P-tau was not consistently related to WMH occurrence. Our findings indicate that cerebral amyloid burden is associated with WMHs located in specific posterior white matter regions, possibly reflecting region-specific effects of amyloid pathology on the white matter.
| Type: | Article |
|---|---|
| Title: | Cerebral amyloid burden is associated with white matter hyperintensity location in specific posterior white matter regions |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neurobiolaging.2019.08.001 |
| Publisher version: | https://doi.org/10.1016/j.neurobiolaging.2019.08.0... |
| Language: | English |
| Additional information: | © 2019The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Alzheimer's disease, Amyloid-beta, Cerebrospinal fluid, Lesion mapping, Magnetic resonance imaging, Tau, White matter hyperintensities |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10082744 |
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