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Advances in nanoparticle development for improved therapeutics delivery: nanoscale topographical aspect

Singh, RK; Knowles, JC; Kim, H-W; (2019) Advances in nanoparticle development for improved therapeutics delivery: nanoscale topographical aspect. Journal of Tissue Engineering , 10 10.1177/2041731419877528. Green open access

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Abstract

Nanoparticle-based therapeutics delivery holds great promise for the treatment of intractable diseases. The high loading of drug molecules and their precise delivery to target sites are needed to gain optimal therapeutic functions of the nanoparticle delivery system. In this communication, we highlight, among other properties of nanoparticles (e.g. size, shape, surface chemistry, and degradation), the nanoscale topography, which has recently been shown to be an important parameter, ultimately determining drug loading, cell penetration, and body clearance. This nanotopographical aspect is considered to offer a new effective strategy to the development of nanoparticles for drug and gene delivery with enhanced therapeutic outcome.

Type: Article
Title: Advances in nanoparticle development for improved therapeutics delivery: nanoscale topographical aspect
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/2041731419877528
Publisher version: https://doi.org/10.1177/2041731419877528
Language: English
Additional information: Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/ en-us/nam/ open-access-at-sage).
Keywords: Therapeutics, nanoparticles, topography, delivery efficiency
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Biomaterials and Tissue Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10082578
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