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Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe

Raveane, A; Aneli, S; Montinaro, F; Athanasiadis, G; Barlera, S; Birolo, G; Boncoraglio, G; ... Capelli, C; + view all (2019) Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe. Science Advances , 5 (9) , Article eaaw3492. 10.1126/sciadv.aaw3492. Green open access

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Abstract

European populations display low genetic differentiation as the result of long-term blending of their ancient founding ancestries. However, it is unclear how the combination of ancient ancestries related to early foragers, Neolithic farmers, and Bronze Age nomadic pastoralists can explain the distribution of genetic variation across Europe. Populations in natural crossroads like the Italian peninsula are expected to recapitulate the continental diversity, but have been systematically understudied. Here, we characterize the ancestry profiles of Italian populations using a genome-wide dataset representative of modern and ancient samples from across Italy, Europe, and the rest of the world. Italian genomes capture several ancient signatures, including a non-steppe contribution derived ultimately from the Caucasus. Differences in ancestry composition, as the result of migration and admixture, have generated in Italy the largest degree of population structure detected so far in the continent, as well as shaping the amount of Neanderthal DNA in modern-day populations.

Type: Article
Title: Population structure of modern-day Italians reveals patterns of ancient and archaic ancestries in Southern Europe
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/sciadv.aaw3492
Publisher version: https://doi.org/10.1126/sciadv.aaw3492
Language: English
Additional information: Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/10082308
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