Gilbert, R;
Peto, T;
Lengyel, I;
Emri, E;
(2019)
Zinc Nutrition and Inflammation in the Aging Retina.
Molecular Nutrition & Food Research
, 63
(15)
, Article 1801049. 10.1002/mnfr.201801049.
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Abstract
Zinc is an essential nutrient for human health. It plays key roles in maintaining protein structure and stability, serves as catalytic factor for many enzymes, and regulates diverse fundamental cellular processes. Zinc is important in affecting signal transduction and, in particular, in the development and integrity of the immune system, where it affects both innate and adaptive immune responses. The eye, especially the retina‐choroid complex, has an unusually high concentration of zinc compared to other tissues. The highest amount of zinc is concentrated in the retinal pigment epithelium (RPE) (RPE‐choroid, 292 ± 98.5 µg g−1 dry tissue), followed by the retina (123 ± 62.2 µg g−1 dry tissue). The interplay between zinc and inflammation has been explored in other parts of the body but, so far, has not been extensively researched in the eye. Several lines of evidence suggest that ocular zinc concentration decreases with age, especially in the context of age‐related disease. Thus, a hypothesis that retinal function could be modulated by zinc nutrition is proposed, and subsequently trialled clinically. In this review, the distribution and the potential role of zinc in the retina‐choroid complex is outlined, especially in relation to inflammation and immunity, and the clinical studies to date are summarized.
| Type: | Article |
|---|---|
| Title: | Zinc Nutrition and Inflammation in the Aging Retina |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mnfr.201801049 |
| Publisher version: | https://doi.org/10.1002/mnfr.201801049 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit https://creativecommons.org/licenses/by-nc/4.0/deed.en |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Food Science & Technology, age-related macular degeneration (AMD), inflammation, retina, supplements, T-cells, zinc, COMPLEMENT FACTOR-H, REGULATORY T-CELLS, ABNORMAL DARK-ADAPTATION, ERG B-WAVE, MACULAR DEGENERATION, ENDOGENOUS ZINC, GUT MICROBIOTA, PIGMENT EPITHELIUM, BRUCHS MEMBRANE, DIETARY ANTIOXIDANTS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10082287 |
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