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Glucocorticoids accelerate maturation of the heme pathway in fetal liver through effects on transcription and DNA methylation

Khulan, B; Liu, L; Rose, CM; Boyle, AK; Manning, JR; Drake, AJ; (2016) Glucocorticoids accelerate maturation of the heme pathway in fetal liver through effects on transcription and DNA methylation. Epigenetics , 11 (2) pp. 103-109. 10.1080/15592294.2016.1144006. Green open access

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Abstract

Glucocorticoids are widely used in threatened preterm labor to promote maturation in many organ systems in preterm babies and have significant beneficial effects on morbidity and mortality. We performed transcriptional profiling in fetal liver in a rat model of prenatal glucocorticoid exposure and identified marked gene expression changes in heme biosynthesis, utilization, and degradation pathways in late gestation. These changes in gene expression associated with alterations in DNA methylation and with a reduction in hepatic heme concentration. There were no persistent differences in gene expression, DNA methylation, or heme concentrations at 4 weeks of age, suggesting that these are transient effects. Our findings are consistent with glucocorticoid-induced accelerated maturation of the haematopoietic system and support the hypothesis that glucocorticoids can drive changes in gene expression in association with alterations in DNA methylation.

Type: Article
Title: Glucocorticoids accelerate maturation of the heme pathway in fetal liver through effects on transcription and DNA methylation
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/15592294.2016.1144006
Publisher version: https://doi.org/10.1080/15592294.2016.1144006
Language: English
Additional information: Copyright © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC©Batbayar Khulan, Lincoln Liu, Catherine M. Rose, Ashley K. Boyle, Jonathan R. Manning, and Amanda J. Drake. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
Keywords: DNA methylation, glucocorticoids, heme, liver, prenatal, Animals, Cytochrome P-450 Enzyme System, DNA Methylation, Dexamethasone, Epigenesis, Genetic, Female, Fetal Development, Gene Expression Profiling, Glucocorticoids, Heme, Liver, Male, Maternal Exposure, Pregnancy, Promoter Regions, Genetic, Rats, Rats, Wistar, Transcriptome
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10082096
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