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Cathelicidins and the Onset of Labour

Boeckel, SRV; Hrabalkova, L; Baker, TL; MacPherson, H; Frew, L; Boyle, AK; McHugh, BJ; ... Stock, SJ; + view all (2019) Cathelicidins and the Onset of Labour. Scientific Reports , 9 , Article 7356. 10.1038/s41598-019-43766-7. Green open access

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Abstract

Preterm birth, defned as delivery before 37 weeks of gestation, is the leading cause of neonatal mortality and morbidity. Infection and infammation are frequent antecedents of spontaneous preterm birth. Cathelicidin, an antimicrobial host defence peptide, is induced by infection and infammation and although expressed in the reproductive tract and fetal tissues, its role in the pathogenesis of spontaneous preterm birth is unknown. Here we demonstrate that cathelicidin expression is increased at RNA and protein level in the mouse uterus in a model of infammation-induced labour, where ultrasound guided intrauterine injection of lipopolysaccharide (LPS) at E17 stimulates preterm delivery within 24hours. Cathelicidin-defcient (Camp−/−) mice are less susceptible to preterm delivery than wild type mice following intrauterine injection of 1μg of LPS, and this is accompanied by a decrease in circulating IL-6, an infammatory mediator implicated in the onset of labour. We also show that the proportion of cathelicidin expressing cells in the myometrium is higher in samples obtained from women in labour at term than pre-labour. Together, these data suggest that cathelicidin has roles in mediating pro-infammatory responses in a murine model of infammation-induced labour, and in human term labour.

Type: Article
Title: Cathelicidins and the Onset of Labour
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41598-019-43766-7
Publisher version: https://doi.org/10.1038/s41598-019-43766-7
Language: English
Additional information: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10082092
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