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Electrospinning of Cellulose Based Wound Dressing

Crabbe-Mann, Maryam Rachel; (2019) Electrospinning of Cellulose Based Wound Dressing. Doctoral thesis (Ph.D), UCL (University College London). Green open access

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Abstract

Cellulose is the most abundant polymer found on the face of the earth with plants and bacteria producing over 1011 103 kg every year. Not only is this material widely available, it is renewable, sustainable and cheap, making it an attractive selection across many industries. The return to naturally derived materials in the medical field is driven by two motivations; the increased cases of resistance in bacteria to conventional drugs, and more relatedly, the need to reduce dependence on non-renewable resources when producing medical materials. Cellulose and its derivatives, are already used widely in the biomedical field in varying applications; drug delivery to eye drops. When manufacturing biomaterials from cellulose, the techniques used usually contain many steps and can be quite costly, this is where electrohydrodynamic (EHD) processing comes in. EHD is a one step process where under the influence of an electric field, a polymer solution or melt can be processed into micro- and nano-scale structures as a function of the polymer solution/melt properties such as concentration, molecular weight, solvent and processing properties such as voltage, flow rate and collection distance. In the first instance, this work investigated the electrospinning of three cellulose derivatives, ethyl cellulose, cellulose acetate and carboxymethyl cellulose; changing parameters aforementioned and observing the effect on the microstructures produced. Bacterial cellulose produced by the Gluconacetobacter xylinus bacteria, is chemically identical to plant cellulose, but is purer, not needing any separation or purifying post production. The most attractive feature of this bacterial cellulose (BC) is its liquid absorption capacity, it can hold many times it weight in liquid and proves to be useful in managing the exudate of diabetic ulcers. This BC was blended with different polymers and anti-diabetic drugs, after which in vitro behaviour was assessed.

Type: Thesis (Doctoral)
Qualification: Ph.D
Title: Electrospinning of Cellulose Based Wound Dressing
Event: UCL
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Copyright © The Author 2019. Original content in this thesis is licensed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/by/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10082026
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