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Vaccine Effectiveness against DS-1-Like Rotavirus Strains in Infants with Acute Gastroenteritis, Malawi, 2013-2015

Jere, KC; Bar-Zeev, N; Chande, A; Bennett, A; Pollock, L; Sanchez-Lopez, PF; Nakagomi, O; ... Cunliffe, NA; + view all (2019) Vaccine Effectiveness against DS-1-Like Rotavirus Strains in Infants with Acute Gastroenteritis, Malawi, 2013-2015. Emerging Infectious Diseases , 25 (9) pp. 1734-1737. 10.3201/eid2509.190258. Green open access

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Abstract

Atypical DS-1-like G1P[8] rotaviruses emerged in 2013 in Malawi after rotavirus vaccine introduction. Vaccine effectiveness among infants hospitalized with acute DS-1-like G1P[8] rotavirus gastroenteritis was 85.6% (95% CI 34.4%-96.8%). These findings suggest that vaccine provides protection against these strains despite their emergence coinciding with vaccine introduction.

Type: Article
Title: Vaccine Effectiveness against DS-1-Like Rotavirus Strains in Infants with Acute Gastroenteritis, Malawi, 2013-2015
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.3201/eid2509.190258
Publisher version: http://dx.doi.org/10.3201/eid2509.190258
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Malawi, genome constellation, genotyping, infants, rotavirus, vaccine effectiveness, vaccines, viruses, whole-genome sequencing
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10081929
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