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Genetic predisposition and modifiable risks for late-life dementia

Rockwood, K; Wallace, LMK; Davis, DH; (2019) Genetic predisposition and modifiable risks for late-life dementia. Nature Medicine , 25 (9) pp. 1331-1332. 10.1038/s41591-019-0575-3. Green open access

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Abstract

Dementia is a syndrome of cognitive and functional impairment. Although age remains the primary risk factor, several other diverse risks have been linked with dementia, including genetic factors, such as the presence of the APOE4 allele, and lifestyle factors including smoking and exercise. With ever-aging populations, interventions that offer some prospect of dementia prevention are being scrutinized. A critical issue is how the genetic and lifestyle factors interact; that is, whether the genetic risk for dementia can be modified by a healthful lifestyle. In this issue, Licher et al.1 have found that modifiable lifestyle risk factors were able to decrease dementia risk only in people with low genetic risk. This finding is in contrast to those from previous studies showing that lifestyle is able to mitigate the effects of genetic risk on the development of dementia.

Type: Article
Title: Genetic predisposition and modifiable risks for late-life dementia
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41591-019-0575-3
Publisher version: https://doi.org/10.1038/s41591-019-0575-3
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Dementia, Risk factors
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine > MRC Unit for Lifelong Hlth and Ageing
URI: https://discovery.ucl.ac.uk/id/eprint/10081912
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