Ryom, L;
Lundgren, JD;
Reiss, P;
Kirk, O;
Law, M;
Ross, M;
Morlat, P;
... D:A:D Study Group, .; + view all
(2019)
Use of contemporary protease inhibitors and risk of incident chronic kidney disease in HIV-positive persons; the D:A:D Study.
Journal of Infectious Diseases
, Article jiz369. 10.1093/infdis/jiz369.
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Abstract
BACKGROUND: It is unclear if use of contemporary protease inhibitors (PIs) pose a similar chronic kidney disease (CKD) risk as older PIs. // METHODS: D:A:D participants were followed to CKD, last visit or 2016. Adjusted Poisson regression assessed associations between CKD and boosted atazanavir (ATV/r) and darunavir (DRV/r). // RESULTS: CKD incidence (10.0/1000 PYFU [95%CI 9.5-10.4]) increased gradually with increasing exposure to ATV/r, but less clearly for DRV/r. After adjustment, only exposure to ATV/r (1.4 [1.2-1.6]), but not DRV/r (1.0 [0.8-1.3]) remained significantly associated with CKD. // CONCLUSION: While DRV/r use was not significantly associated with CKD an increasing incidence with longer ATV/r use was confirmed.
| Type: | Article |
|---|---|
| Title: | Use of contemporary protease inhibitors and risk of incident chronic kidney disease in HIV-positive persons; the D:A:D Study |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/infdis/jiz369 |
| Publisher version: | https://doi.org/10.1093/infdis/jiz369 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | CKD, HIV, adverse drug effect, atazanavir, darunavir, nephrotoxicity, protease inhibitors |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10081850 |
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