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Use of contemporary protease inhibitors and risk of incident chronic kidney disease in HIV-positive persons; the D:A:D Study

Ryom, L; Lundgren, JD; Reiss, P; Kirk, O; Law, M; Ross, M; Morlat, P; ... D:A:D Study Group, .; + view all (2019) Use of contemporary protease inhibitors and risk of incident chronic kidney disease in HIV-positive persons; the D:A:D Study. Journal of Infectious Diseases , Article jiz369. 10.1093/infdis/jiz369. Green open access

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Abstract

BACKGROUND: It is unclear if use of contemporary protease inhibitors (PIs) pose a similar chronic kidney disease (CKD) risk as older PIs. // METHODS: D:A:D participants were followed to CKD, last visit or 2016. Adjusted Poisson regression assessed associations between CKD and boosted atazanavir (ATV/r) and darunavir (DRV/r). // RESULTS: CKD incidence (10.0/1000 PYFU [95%CI 9.5-10.4]) increased gradually with increasing exposure to ATV/r, but less clearly for DRV/r. After adjustment, only exposure to ATV/r (1.4 [1.2-1.6]), but not DRV/r (1.0 [0.8-1.3]) remained significantly associated with CKD. // CONCLUSION: While DRV/r use was not significantly associated with CKD an increasing incidence with longer ATV/r use was confirmed.

Type: Article
Title: Use of contemporary protease inhibitors and risk of incident chronic kidney disease in HIV-positive persons; the D:A:D Study
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/infdis/jiz369
Publisher version: https://doi.org/10.1093/infdis/jiz369
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: CKD, HIV, adverse drug effect, atazanavir, darunavir, nephrotoxicity, protease inhibitors
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/10081850
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