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Positron Emission Tomography, Computed Tomography, Magnetic Resonance Imaging and Staging in colorectal cancer.

Dindyal, Sanjay; (2019) Positron Emission Tomography, Computed Tomography, Magnetic Resonance Imaging and Staging in colorectal cancer. Doctoral thesis (M.D(Res)), UCL (University College London). Green open access

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Abstract

The value of positron emission tomography magnetic resonance imaging (PET/MRI) and positron emission tomography computed tomography (PET/CT) in oncological imaging is based on the fundamental principle that abnormal alterations in intra-cellular biochemical reactions result in the development of malignancy. Positron-emitting analogue tracers may be synthesised from organic matter and utilised to demonstrate these intra-cellular sequential processes. The principle aim of this study was to prospectively evaluate if PET/MRI may be considered to be a more accurate imaging modality than PET/CT or an equivalent or complimentary imaging modality to conventional imaging (CT or MRI) for the complete staging of patients with primary colon and rectal cancers. The purpose was to conduct investigations to enable evaluation of the diagnostic accuracy of PET/MRI and PET/CT for T, N and M colon and rectal cancer staging in a clinical setting. The work in this thesis may help to evaluate PET/MRI as a new imaging modality by providing high-resolution anatomical, molecular and functional information, which in combination may allow the comprehensive assessment of tumour location and stage in a single imaging examination. PET/MRI may also potentially provide loco-regional and systemic staging of CRC disease. Through incorporation into CRC protocols, patient pathways may be streamlined and provide an effective algorithm for more appropriate and timely treatment, resulting in improved long-term survival.

Type: Thesis (Doctoral)
Qualification: M.D(Res)
Title: Positron Emission Tomography, Computed Tomography, Magnetic Resonance Imaging and Staging in colorectal cancer.
Event: UCL (University College London)
Open access status: An open access version is available from UCL Discovery
Language: English
Additional information: Copyright © The Author 2019. Original content in this thesis is licensed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) Licence (https://creativecommons.org/licenses/by/4.0/). Any third-party copyright material present remains the property of its respective owner(s) and is licensed under its existing terms. Access may initially be restricted at the author’s request.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10081701
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