Gatt, A;
Ekonomou, A;
Somani, A;
Thuret, S;
Howlett, D;
Corbett, A;
Johnson, M;
... Ballard, C; + view all
(2018)
Importance of Proactive Treatment of Depression in Lewy Body Dementias: The Impact on Hippocampal Neurogenesis and Cognition in a Post-Mortem Study.
Dementia and Geriatric Cognitive Disorders
, 44
(5-6)
pp. 283-293.
10.1159/000484437.
Preview |
Text
Gatt_AAM_Dem and Cog manuscript 170825.pdf - Accepted Version Download (540kB) | Preview |
Abstract
OBJECTIVE: To examine the impact of selective serotonin reuptake inhibitors (SSRIs) and depression on neurogenesis and cognition in dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD). // METHODS: Late-stage progenitor cells were quantified in the subgranular zone (SGZ) of the hippocampal dentate gyrus of DLB/PDD patients (n = 41) and controls without dementia (n = 15) and compared between treatment groups (unmedicated, SSRIs, acetyl cholinesterase inhibitors [AChEIs], combined SSRIs and AChEIs). // RESULTS: DLB/PDD patients had more doublecortin-positive cells in the SGZ compared to controls. The doublecortin-positive cell count was higher in the SGZ of patients treated with SSRIs and correlated to higher cognitive scores. // CONCLUSION: SSRI treatment was associated with increased hippocampal neurogenesis and preservation of cognition in DLB/PDD patients.
Archive Staff Only
 |
View Item |
