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Genetic and Environmental Associations With Pediatric Cerebral Arteriopathy Insights Into Disease Mechanisms

McCrea, N; Fullerton, HJ; Ganesan, V; (2019) Genetic and Environmental Associations With Pediatric Cerebral Arteriopathy Insights Into Disease Mechanisms. Stroke , 50 (2) pp. 257-265. 10.1161/STROKEAHA.118.020479. Green open access

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Abstract

Mechanisms underlying childhood arterial ischemic stroke (AIS) are heterogeneous and poorly understood but critical for the development of targeted interventions. Current evidence suggests interplay between (mostly) rare genetic risk factors and common environmental exposures. Here, we explore this interplay in relation to cerebral arteriopathies associated with childhood AIS.

Type: Article
Title: Genetic and Environmental Associations With Pediatric Cerebral Arteriopathy Insights Into Disease Mechanisms
Open access status: An open access version is available from UCL Discovery
DOI: 10.1161/STROKEAHA.118.020479
Publisher version: https://doi.org/10.1161/STROKEAHA.118.020479
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Peripheral Vascular Disease, Neurosciences & Neurology, Cardiovascular System & Cardiology, arteries, biomarkers, consensus, mutations, stroke, ARTERIAL ISCHEMIC-STROKE, MOYAMOYA-DISEASE, RISK-FACTORS, EARLY-ONSET, CHILDHOOD, CHILDREN, INFECTION, ABNORMALITIES, POPULATION, DISSECTION
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10081311
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