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Dyslipidaemias and cardiovascular disease: Focus on the role of PCSK9 inhibitors

Panagiotopoulou, O; Chiesa, S; Tousoulis, D; Charakida, M; (2020) Dyslipidaemias and cardiovascular disease: Focus on the role of PCSK9 inhibitors. Current Medicinal Chemistry , 27 (27) pp. 4494-4521. 10.2174/0929867326666190827151012. Green open access

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Abstract

Genetic, experimental and clinical studies have consistently confirmed that inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) can result in significant LDL-C lowering and two fully human PCSK9 mononclonal antibodies have received regulatory approval for use in high-risk patients. Co- administration of PCSK9 with statins has resulted in extremely low LDL-C levels with excellent short-term safety profiles. While results from Phase III clinical trials provided exciting evidence about the role of PCSK9 inhibitors in reducing cardiovascular event rates, their impact on mortality remains less clear. PCSK9 inhibitor therapy can be considered for high risk patients who are likely to experience the largest cardiovascular risk reduction benefit.

Type: Article
Title: Dyslipidaemias and cardiovascular disease: Focus on the role of PCSK9 inhibitors
Open access status: An open access version is available from UCL Discovery
DOI: 10.2174/0929867326666190827151012
Publisher version: https://doi.org/10.2174/0929867326666190827151012
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: PCSK9, Proprotein Convertase Subtilisin/Kexin type 9, Alirocumab, Evolocumab, LDL-cholesterol, monoclonal antibodies
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: https://discovery.ucl.ac.uk/id/eprint/10080988
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