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Pulmonary Involvement during the Ebola Virus Disease

Lalle, E; Biava, M; Nicastri, E; Colavita, F; Di Caro, A; Vairo, F; Lanini, S; ... Ippolito, G; + view all (2019) Pulmonary Involvement during the Ebola Virus Disease. Viruses , 11 (9) , Article 780. 10.3390/v11090780. Green open access

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Abstract

Filoviruses have become a worldwide public health concern, especially during the 2013-2016 Western Africa Ebola virus disease (EVD) outbreak-the largest outbreak, both by number of cases and geographical extension, recorded so far in medical history. EVD is associated with pathologies in several organs, including the liver, kidney, and lung. During the 2013-2016 Western Africa outbreak, Ebola virus (EBOV) was detected in the lung of infected patients suggesting a role in lung pathogenesis. However, little is known about lung pathogenesis and the controversial issue of aerosol transmission in EVD. This review highlights the pulmonary involvement in EVD, with a special focus on the new data emerging from the 2013-2016 Ebola outbreak.

Type: Article
Title: Pulmonary Involvement during the Ebola Virus Disease
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/v11090780
Publisher version: https://doi.org/10.3390/v11090780
Language: English
Additional information: This is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Ebola virus, Ebola virus disease, lung pathogenesis, respiratory disease
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10080889
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