Ferocino, E;
Pifferi, A;
Arridge, S;
Martelli, F;
Taroni, P;
Farina, A;
(2019)
Multi Simulation Platform for Time Domain Diffuse Optical Tomography: An Application to a Compact Hand-Held Reflectance Probe.
Applied Science
, 9
(14)
, Article 2849. 10.3390/app9142849.
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Abstract
Time Domain Diffuse Optical Tomography (TD-DOT) enables a full 3D reconstruction of the optical properties of tissue, and could be used for non-invasive and cost-effective in-depth body exploration (e.g., thyroid and breast imaging). Performance quantification is crucial for comparing results coming from different implementations of this technique. A general-purpose simulation platform for TD-DOT clinical systems was developed with a focus on performance assessment through meaningful figures of merit. The platform was employed for assessing the feasibility and characterizing a compact hand-held probe for breast imaging and characterization in reflectance geometry. Important parameters such as hardware gating of the detector, photon count rate and inclusion position were investigated. Results indicate a reduced error (<10%) on the absorption coefficient quantification of a simulated inclusion up to 2-cm depth if a photon count rate ≥ 10^{6} ounts per second is used along with a good localization (error < 1 mm down to 25 mm-depth).
Type: | Article |
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Title: | Multi Simulation Platform for Time Domain Diffuse Optical Tomography: An Application to a Compact Hand-Held Reflectance Probe |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.3390/app9142849 |
Publisher version: | https://doi.org/10.3390/app9142849 |
Language: | English |
Additional information: | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | diffuse optics; optical mammography; diffuse optical tomography; time domain |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science |
URI: | https://discovery.ucl.ac.uk/id/eprint/10080527 |
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