UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Screening with a high precision blood-based assay for Alzheimer disease

Bendlin, BB; Zetterberg, H; (2019) Screening with a high precision blood-based assay for Alzheimer disease. [Editorial comment]. Neurology 10.1212/WNL.0000000000008080. (In press).

[img] Text
Zetterberg_Screening with a high precision blood-based assay for Alzheimer disease_AAM.pdf - Accepted version
Access restricted to UCL open access staff

Download (128kB)

Abstract

The use of biomarkers for defining the pathobiology of Alzheimer disease (AD) has had a transformative effect on the field, facilitating disease detection prior to autopsy, as well as substantially altering clinical trial design.1 In the last 5–10 years, there has been a substantial shift toward using amyloid PET in human research, as well as clinically, to rule out AD (a negative scan meaning little or no plaque is present). Likewise, obtaining a sample of CSF via lumbar puncture provides a plethora of information on amyloid plaque burden, tau pathology, neurodegeneration, and gliosis. While amyloid PET and CSF β-amyloid (Aβ)42/Aβ40 have excellent diagnostic accuracy, and correspond well with plaque burden measured postmortem,2 it is widely recognized that access to a simple blood test for AD would change the field yet again.

Type: Article
Title: Screening with a high precision blood-based assay for Alzheimer disease
Location: United States
DOI: 10.1212/WNL.0000000000008080
Publisher version: https://doi.org/10.1212/WNL.0000000000008080
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10080522
Downloads since deposit
1Download
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item