Bendlin, BB;
Zetterberg, H;
(2019)
Screening with a high precision blood-based assay for Alzheimer disease.
[Editorial comment].
Neurology
10.1212/WNL.0000000000008080.
(In press).
Text
Zetterberg_Screening with a high precision blood-based assay for Alzheimer disease_AAM.pdf - Accepted Version Access restricted to UCL open access staff Download (128kB) |
Abstract
The use of biomarkers for defining the pathobiology of Alzheimer disease (AD) has had a transformative effect on the field, facilitating disease detection prior to autopsy, as well as substantially altering clinical trial design.1 In the last 5–10 years, there has been a substantial shift toward using amyloid PET in human research, as well as clinically, to rule out AD (a negative scan meaning little or no plaque is present). Likewise, obtaining a sample of CSF via lumbar puncture provides a plethora of information on amyloid plaque burden, tau pathology, neurodegeneration, and gliosis. While amyloid PET and CSF β-amyloid (Aβ)42/Aβ40 have excellent diagnostic accuracy, and correspond well with plaque burden measured postmortem,2 it is widely recognized that access to a simple blood test for AD would change the field yet again.
Type: | Article |
---|---|
Title: | Screening with a high precision blood-based assay for Alzheimer disease |
Location: | United States |
DOI: | 10.1212/WNL.0000000000008080 |
Publisher version: | https://doi.org/10.1212/WNL.0000000000008080 |
Language: | English |
Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
URI: | https://discovery.ucl.ac.uk/id/eprint/10080522 |
Archive Staff Only
View Item |