Iannone, LF;
Preda, A;
Blottiere, HM;
Clarke, G;
Albani, D;
Belcastro, V;
Carotenuto, M;
... Striano, P; + view all
(2019)
Microbiota-gut brain axis involvement in neuropsychiatric disorders.
Expert Review of Neurotherapeutics
, 19
(10)
pp. 1037-1050.
10.1080/14737175.2019.1638763.
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Abstract
Introduction: The microbiota-gut brain (MGB) axis is the bidirectional communication between the intestinal microbiota and the brain. An increasing body of preclinical and clinical evidence has revealed that the gut microbial ecosystem can affect neuropsychiatric health. However, there is still a need of further studies to elucidate the complex gene–environment interactions and the role of the MGB axis in neuropsychiatric diseases, with the aim of identifying biomarkers and new therapeutic targets, to allow early diagnosis and improving treatments. Areas covered: To review the role of MGB axis in neuropsychiatric disorders, prediction and prevention of disease through exploitation, integration, and combination of data from existing gut microbiome/microbiota projects and appropriate other International ‘-Omics’ studies. The authors also evaluated the new technological advances to investigate and modulate, through nutritional and other interventions, the gut microbiota. Expert opinion: The clinical studies have documented an association between alterations in gut microbiota composition and/or function, whereas the preclinical studies support a role for the gut microbiota in impacting behaviors which are of relevance to psychiatry and other central nervous system (CNS) disorders. Targeting MGB axis could be an additional approach for treating CNS disorders and all conditions in which alterations of the gut microbiota are involved.
| Type: | Article |
|---|---|
| Title: | Microbiota-gut brain axis involvement in neuropsychiatric disorders |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/14737175.2019.1638763 |
| Publisher version: | https://doi.org/10.1080/14737175.2019.1638763 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Pharmacology & Pharmacy, Neurosciences & Neurology, Ketogenic diet, microbiota-gut brain axis, inflammation, manipulating microbiota, metabolomics, neuropsychiatric disorders, AUTISM SPECTRUM DISORDERS, CENTRAL-NERVOUS-SYSTEM, GRADIENT GEL-ELECTROPHORESIS, FECAL MICROBIOTA, MULTIPLE-SCLEROSIS, INTESTINAL MICROBIOTA, PARKINSONS-DISEASE, KETOGENIC DIET, AUTOIMMUNE ENCEPHALOMYELITIS, ENVIRONMENT INTERACTIONS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Experimental Epilepsy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10080419 |
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