Sgro, GG;
Oka, GU;
Souza, DP;
Cenens, W;
Bayer-Santos, E;
Matsuyama, BY;
Bueno, NF;
... Farah, CS; + view all
(2019)
Bacteria-Killing Type IV Secretion Systems.
[Review].
Frontiers In Microbiology
, 10
, Article 1078. 10.3389/fmicb.2019.01078.
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Abstract
Bacteria have been constantly competing for nutrients and space for billions of years. During this time, they have evolved many different molecular mechanisms by which to secrete proteinaceous effectors in order to manipulate and often kill rival bacterial and eukaryotic cells. These processes often employ large multimeric transmembrane nanomachines that have been classified as types I–IX secretion systems. One of the most evolutionarily versatile are the Type IV secretion systems (T4SSs), which have been shown to be able to secrete macromolecules directly into both eukaryotic and prokaryotic cells. Until recently, examples of T4SS-mediated macromolecule transfer from one bacterium to another was restricted to protein-DNA complexes during bacterial conjugation. This view changed when it was shown by our group that many Xanthomonas species carry a T4SS that is specialized to transfer toxic bacterial effectors into rival bacterial cells, resulting in cell death. This review will focus on this special subtype of T4SS by describing its distinguishing features, similar systems in other proteobacterial genomes, and the nature of the effectors secreted by these systems and their cognate inhibitors
| Type: | Article |
|---|---|
| Title: | Bacteria-Killing Type IV Secretion Systems |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fmicb.2019.01078 |
| Publisher version: | https://doi.org/10.3389/fmicb.2019.01078 |
| Language: | English |
| Additional information: | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. https://creativecommons.org/licenses/by/4.0/ |
| Keywords: | bacterial competition, Xanthomonadales, type IV immunity protein, type IV secretion effector, type IV secretion system, X-Tfe, X-Tfi, X-T4SS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10080306 |
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