UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Oromucosal films: from patient centricity to production by printing techniques

Tian, Y; Orlu, M; Woerdenbag, HJ; Scarpa, M; Kiefer, O; Kottke, D; Sjöholm, E; ... Visser, JC; + view all (2019) Oromucosal films: from patient centricity to production by printing techniques. Expert Opinion on Drug Delivery , 16 (9) pp. 981-993. 10.1080/17425247.2019.1652595. Green open access

[thumbnail of Orlu_Oromucosal films. From patient centricity to production by printing techniques_VoR.pdf]
Preview
Text
Orlu_Oromucosal films. From patient centricity to production by printing techniques_VoR.pdf

Download (1MB) | Preview

Abstract

INTRODUCTION: Oromucosal films, comprising mucoadhesive buccal films (MBFs) and orodispersible films (ODFs), are considered patient-centric dosage forms. Target groups are patients with special needs. Various active pharmaceutical ingredients have been shown to be suitable for oromucosal film production. A shift is seen in the production techniques, from conventional solvent casting to printing techniques. AREAS COVERED: In this review, the patient acceptability of oromucosal films is discussed. An overview is given of the small molecule drugs, biopharmaceuticals and herbal extracts that have been incorporated so far. Finally, the current state of 2D and 3D printing techniques for production purposes is discussed. EXPERT OPINION: The patient-centric features are important for the further development and acceptance of this oral solid dosage form. Oromucosal films perfectly fit in the current attention for personalized medicine. Both MBFs and ODFs are intended for either a local or a systemic effect. For buccal absorption, sufficient mucoadhesion is one of the most important criteria an oromucosal film must comply with. For the preparation, the solvent casting technique is still predominately used. Some limitations of this production method can be tackled by printing techniques. However, these novel techniques introduce new requirements, yet to be set, for oromucosal film preparation.

Type: Article
Title: Oromucosal films: from patient centricity to production by printing techniques
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/17425247.2019.1652595
Publisher version: https://doi.org/10.1080/17425247.2019.1652595
Language: English
Additional information: © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Local drug delivery, mucoadhesive buccal films, orodispersible films, oromucosal films, patient centricity, printing techniques, systemic drug delivery
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10080145
Downloads since deposit
136Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item