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Understanding mortality in multiple myeloma: Findings of a European retrospective chart review

Mohty, M; Cavo, M; Fink, L; Gonzalez-McQuire, S; Leleu, H; Mateos, M-V; Raab, MS; ... Yong, K; + view all (2019) Understanding mortality in multiple myeloma: Findings of a European retrospective chart review. European Journal of Haematology , 103 (2) pp. 107-115. 10.1111/ejh.13264. Green open access

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Abstract

Objectives This study aimed to provide real‐world data on the characteristics and treatment of patients with multiple myeloma (MM) at the time of death. Methods The study was a retrospective patient chart review across France, Germany, Italy, Spain and the UK during 2016, and included patients who had died in the 3 months before the index date. Results Data from 786 patients were reviewed. At the time of death, 37% of patients were receiving active treatment, 12% were in a treatment‐free interval and 51% were receiving only supportive care. Death before and during active first‐line treatment was not uncommon (6% and 24% of patients, respectively) but these deaths were often not solely due to disease progression; factors such as renal failure and infection frequently played a role (in 30% and 20% of patients at first‐line, respectively). Most deaths at later lines were due to progressive disease. Cox model results suggested that early deaths were associated with advanced disease stage, high‐risk cytogenetics and poor response and relapse profiles. Conclusions These real‐world data could be used to help develop strategies for improving survival in patients with MM and to support management tailored to the stage of disease.

Type: Article
Title: Understanding mortality in multiple myeloma: Findings of a European retrospective chart review
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/ejh.13264
Publisher version: https://doi.org/10.1111/ejh.13264
Language: English
Additional information: This is an open access article under the terms of the Creative Commons Attribution NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Keywords: Science & Technology, Life Sciences & Biomedicine, Hematology, death, Europe, mortality, multiple myeloma, risk, survival, INTERNATIONAL STAGING SYSTEM, SURVIVAL, RISK, COMORBIDITY, PATTERNS, IMPACT
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: https://discovery.ucl.ac.uk/id/eprint/10080070
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