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Cardiac Amyloidosis: Updates in Imaging

Chacko, L; Martone, R; Cappelli, F; Fontana, M; (2019) Cardiac Amyloidosis: Updates in Imaging. Current Cardiology Reports , 21 (9) , Article 108. 10.1007/s11886-019-1180-2. Green open access

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Abstract

PURPOSE OF REVIEW: We summarize key features pertaining to the two most commonly encountered types of cardiac amyloidosis (CA), monoclonal immunoglobulin light chain (AL) and transthyretin type (ATTR), expanding upon the clinical application and utility of various imaging techniques in diagnosing CA. // RECENT FINDINGS: Advances in imaging have led to earlier identification, improved diagnosis of CA and higher discriminatory power to differentiate CA from other hypertrophic phenocopies. The application of cardiac magnetic resonance imaging (CMR) has led to a deeper understanding of underlying pathophysiological processes in CA, owing largely to its intrinsic tissue characterization properties. The widespread adoption of bone scintigraphy algorithms has reduced the need for cardiac biopsy and improved diagnostic confidence in ATTR CA. // SUMMARY: As new treatments for CA are rapidly developing, there will be even greater reliance on imaging, as the requirement to diagnose disease earlier, monitor response and amend treatment strategies accordingly intensifies.

Type: Article
Title: Cardiac Amyloidosis: Updates in Imaging
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s11886-019-1180-2
Publisher version: https://doi.org/10.1007/s11886-019-1180-2
Language: English
Additional information: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/ licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Cardiac amyloidosis, Cardiomyopathy, Echocardiography, Immunoglobulin light chain, Magnetic resonance imaging, Transthyretin
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10080067
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