UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Current and Emerging Methods of Management of Ependymoma

Toescu, SM; Aquilina, K; (2019) Current and Emerging Methods of Management of Ependymoma. Current Oncology Reports , 21 (9) , Article 78. 10.1007/s11912-019-0826-y. Green open access

[img]
Preview
Text
Toescu_Current and Emerging Methods of Management of Ependymoma_AAM.pdf - Accepted version

Download (390kB) | Preview

Abstract

PURPOSE OF REVIEW: This review discusses the evidence base behind current and emerging strategies of management of intracranial and spinal ependymomas in children, with a particular focus on aspects of surgical techniques, challenges and complications. RECENT FINDINGS: The cornerstone of management remains maximal safe resective surgery, which has repeatedly been shown to correlate with improved survival. This is followed by focal conformal radiotherapy, although good results using proton beam therapy, with the potential for diminished side effects, are emerging. The role of chemotherapy remains largely unproven for paediatric ependymoma. Despite optimal management strategies, many children with ependymoma suffer from tumour recurrence. SUMMARY: The standard of care for paediatric ependymoma comprises surgery and radiotherapy. Results of ongoing clinical trials will help shape its management in order to leverage our increasingly sophisticated understanding of the genetic drivers behind these tumours into survival benefit for this challenging group of patients.

Type: Article
Title: Current and Emerging Methods of Management of Ependymoma
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s11912-019-0826-y
Publisher version: https://doi.org/10.1007/s11912-019-0826-y
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Ependymoma, Paediatric, Surgery, Cerebellopontine angle, Radiotherapy, Chemotherapy
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
URI: https://discovery.ucl.ac.uk/id/eprint/10079960
Downloads since deposit
84Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item