UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Distinct roles of dopamine and noradrenaline in incidental memory

Hauser, TU; Eldar, E; Purg, N; Moutoussis, M; Dolan, RJ; (2019) Distinct roles of dopamine and noradrenaline in incidental memory. Journal of Neuroscience 10.1523/JNEUROSCI.0401-19.2019. (In press). Green open access

[img]
Preview
Text
Hauser_Distinct roles of dopamine and noradrenaline in incidental memory_AAM2.pdf - Accepted version

Download (749kB) | Preview

Abstract

Episodic memory is sensitive to the influence of neuromodulators, such as dopamine and noradrenaline. These influences are considered important in the expression of several known memory biases, though their specific role in memory remains unclear. Using pharmacological agents with relatively high selectivity for either dopamine (400mg amisulpride) or noradrenaline (40mg propranolol) we examined their specific contribution to incidental memory. In a double-blind placebo-controlled human study (30 females, 30 males in total), we show that a memory selectivity bias was insensitive to propranolol but sensitive to amisulpride, consistent with a dominant influence from dopamine. By contrast, a putative arousal-induced memory boosting effect was insensitive to amisulpride but was sensitive to propranolol, consistent with a dominant noradrenaline effect. Thus, our findings highlight specific functional roles for dopamine and noradrenaline neurotransmission in the expression of incidental memory.

Type: Article
Title: Distinct roles of dopamine and noradrenaline in incidental memory
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.0401-19.2019
Publisher version: https://doi.org/10.1523/JNEUROSCI.0401-19.2019
Language: English
Additional information: © 2019 Hauser et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10079951
Downloads since deposit
25Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item