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Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis

Kataria, M; Yamano, H; (2019) Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis. MDPI — Cells , 8 (8) , Article 814. 10.3390/cells8080814. Green open access

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Abstract

Accurate division of cells into two daughters is a process that is vital to propagation of life. Protein phosphorylation and selective degradation have emerged as two important mechanisms safeguarding the delicate choreography of mitosis. Protein phosphatases catalyze dephosphorylation of thousands of sites on proteins, steering the cells through establishment of the mitotic phase and exit from it. A large E3 ubiquitin ligase, the anaphase-promoting complex/cyclosome (APC/C) becomes active during latter stages of mitosis through G1 and marks hundreds of proteins for destruction. Recent studies have revealed the complex interregulation between these two classes of enzymes. In this review, we highlight the direct and indirect mechanisms by which phosphatases and the APC/C mutually influence each other to ensure accurate spatiotemporal and orderly progression through mitosis, with a particular focus on recent insights and conceptual advances.

Type: Article
Title: Interplay between Phosphatases and the Anaphase-Promoting Complex/Cyclosome in Mitosis
Location: Switzerland
Open access status: An open access version is available from UCL Discovery
DOI: 10.3390/cells8080814
Publisher version: https://doi.org/10.3390/cells8080814
Language: English
Additional information: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Keywords: anaphase-promoting complex/cyclosome (APC/C), cell cycle, cyclin, cyclin-dependent kinase 1 (Cdk1), kinase, mitosis, phosphatase, phosphorylation, ubiquitylation
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
URI: https://discovery.ucl.ac.uk/id/eprint/10079850
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