Petzold, A;
(2018)
Neurodegeneration and multiple sclerosis.
In: Galimberti, D and Scarpini, E, (eds.)
NeurodegeneratIve Diseases: Clinical Aspects, Molecular Genetics and Biomarkers.
(pp. 379-400).
Springer: Cham, Switzerland.
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Abstract
Neurodegeneration causes inexorable loss of neurons and function in both diseases and aging. Neurodegeneration damage produces a range of progressive disabilities from cognitive decline, behavioral and mood disorders to problems with movement, co-ordination, and sensory dysfunction. Neurodegeneration is a major and growing public health issue which in its broadest sense embraces classical neurodegenerative disorders such as Alzheimer’s disease and Parkinson’s disease, as well as multiple sclerosis (MS), diabetes, and acute brain injury among many other conditions. This chapter discusses the clinical and pathophysiological features of neurodegeneration in MS.
| Type: | Book chapter |
|---|---|
| Title: | Neurodegeneration and multiple sclerosis |
| ISBN-13: | 9783319729374 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/978-3-319-72938-1_18 |
| Publisher version: | https://doi.org/10.1007/978-3-319-72938-1_18 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Demyelinating disease, Multiple sclerosis, Neurodegeneration, Trans-synaptic axonal degeneration, Protein biomarker, Cerebrospinal fluid, Retina, Optical coherence tomography |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10079717 |
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