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Depressive symptoms at age 9-13 and chronic disabling fatigue at age 16: A longitudinal study

Collin, SM; Norris, T; Joinson, C; Loades, ME; Lewis, G; Stansfeld, SA; Crawley, E; (2019) Depressive symptoms at age 9-13 and chronic disabling fatigue at age 16: A longitudinal study. Journal of Adolescence , 75 pp. 123-129. 10.1016/j.adolescence.2019.07.014. Green open access

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Abstract

Introduction: We investigated whether depressive symptoms at ages 9–13 years were associated with chronic disabling fatigue (CDF) at age 16 among children in the Avon Longitudinal Study of Parents & Children (ALSPAC) birth cohort. Methods: Depressive symptoms at ages 9, 10, 11, 12, and 13 years were defined as a child- or parent-completed Short Mood and Feelings Questionnaire (SMFQ) score ≥11 (range 0–26). SMFQ score was also analysed as a continuous exposure. Chronic disabling fatigue at 16 was defined as fatigue of ≥6 months' but < 5 years’ duration which prevented school attendance or activities, for which other causes were not identified, and with a Chalder Fatigue Questionnaire score ≥19. Logistic regression was used with multiple imputation to correct for missing data bias. We performed sensitivity analyses in which children who had CDF and depressive symptoms at age 16 were reclassified as not having CDF. Results: In fully adjusted models using imputed data (N = 13,978), depressive symptoms at ages 9, 11, and 13 years were associated with 2- to 3-fold higher odds of CDF at age 16. Each one-point increase in SMFQ score at ages 9, 10, 11, 12, and 13 years was associated with 6–11% higher odds of CDF at age 16. Depressive symptoms and continuous SMFQ scores at each age were not associated with CDF if the outcome was reclassified to exclude children with comorbid depressive symptoms at age 16. Conclusions: Depressive symptoms at ages 9–13 were associated with chronic disabling fatigue at age 16, but causality is not certain.

Type: Article
Title: Depressive symptoms at age 9-13 and chronic disabling fatigue at age 16: A longitudinal study
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.adolescence.2019.07.014
Publisher version: https://doi.org/10.1016/j.adolescence.2019.07.014
Language: English
Additional information: Published by Elsevier Ltd on behalf of The Foundation for Professionals in Services for Adolescents. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
Keywords: ALSPAC, Adolescence, CFS/ME, Chronic fatigue, Mood, Pediatric
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/10079582
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