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Evaluation of Multi-Lead ECG Markers to Track Changes in Dispersion of Ventricular Repolarization in the Intact Human Heart

Orini, M; Srinivasan, N; Taggart, P; Lambiase, PD; (2018) Evaluation of Multi-Lead ECG Markers to Track Changes in Dispersion of Ventricular Repolarization in the Intact Human Heart. In: Computing in Cardiology 2018. IEEE: Maastricht, Netherlands. Green open access

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Abstract

Dispersion of ventricular repolarization (DRT) is an important factor contributing to the vulnerability to life-threatening arrhythmias. An accurate non-invasive methodology for its estimation would contribute to improve risk-prediction. We assessed 3 multi-lead ECG markers to track changes in DRT using intra-cardiac data recorded in patients with structurally normal ventricles. Changes in DRT were measured with intra-cardiac unipolar electrograms (UEG) simultaneously recorded in the RV endocardium (RVendo), LV endocardium (LVendo) and LV epicardium (coronary sinus, LVepi) in 10 patients. Standard S1S2 restitution protocols were conducted by pacing from the RVendo (n = 8), LVendo (n = 10) and LVepi (n = 7). DRT was measured as latest minus earliest repolarization time (RT). In the surface ECG, DRT was estimated from precordial and augmented limb leads as: (1) Interval between the earliest and the latest maximum upslope of the T-wave (∆Tup); (2) Interval between median T-peak and median T-end (Tpe,med); (3) Interval between the earliest T-peak and latest T-end (Tpe,range). Intrapatient correlation with DRT changes was higher using ∆Tup (0.79, 0.66 − 0.89) than Tpe,med (0.61, 0.14 − 0.76, P = 0.001) or Tpe,med (0.71, 0.44 − 0.79, P = 0.054).

Type: Proceedings paper
Title: Evaluation of Multi-Lead ECG Markers to Track Changes in Dispersion of Ventricular Repolarization in the Intact Human Heart
Event: Computing in Cardiology 2018
Location: Maastricht, Netherlands
Dates: September 23-26, 2018
ISBN-13: 9781728109589
Open access status: An open access version is available from UCL Discovery
DOI: 10.22489/CinC.2018.345
Publisher version: https://doi.org/10.22489/CinC.2018.345
Additional information: This is an open-access publication, in which copyright in each article is held by its authors, who grant permission to copy and redistribute their work with attribution, under the terms of the Creative Commons Attribution License https://creativecommons.org/licenses/by/2.5/
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine > MRC Unit for Lifelong Hlth and Ageing
URI: https://discovery.ucl.ac.uk/id/eprint/10079580
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