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Meiotic drive reduces egg-to-adult viability in stalk-eyed flies

Finnegan, S; White, NJ; Koh, D; Camus, MF; Fowler, K; Pomiankowski, A; (2019) Meiotic drive reduces egg-to-adult viability in stalk-eyed flies. Proceedings of the Royal Society B: Biological Sciences , 286 (1910) 10.1098/rspb.2019.1414. Green open access

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Abstract

A number of species are affected by sex ratio meiotic drive (SR), a selfish genetic element located on the X chromosome that causes dysfunction of Y-bearing sperm. SR is transmitted to up to 100% of offspring, causing extreme sex ratio bias. SR in several species is found in a stable polymorphism at a moderate frequency, suggesting there must be strong frequency-dependent selection resisting its spread. We investigate the effect of SR on female and male egg-to-adult viability in the Malaysian stalk-eyed fly, Teleopsis dalmanni. SR meiotic drive in this species is old, and appears to be broadly stable at a moderate (~20%) frequency. We use large-scale controlled crosses to estimate the strength of selection acting against SR in female and male carriers. We find that SR reduces the egg-to-adult viability of both sexes. In females, homozygous females experience greater reduction in viability (sf = 0.242) and the deleterious effects of SR are additive (h = 0.511). The male deficit in viability (sm = 0.214) is not different from that in homozygous females. The evidence does not support the expectation that deleterious side-effects of SR are recessive or sex-limited. We discuss how these reductions in egg-to-adult survival, as well as other forms of selection acting on SR, may maintain the SR polymorphism in this species.

Type: Article
Title: Meiotic drive reduces egg-to-adult viability in stalk-eyed flies
Open access status: An open access version is available from UCL Discovery
DOI: 10.1098/rspb.2019.1414
Publisher version: http://doi.org/10.1098/rspb.2019.1414
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: drive, selfish genetic element, sex ratio, sexual selection, stalk-eyed fly, SR, Teleopsis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/10079575
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