Ali, J;
Rafiq, QA;
Ratcliffe, E;
(2018)
Antimicrobial resistance mechanisms and potential synthetic treatments.
Future Science OA
, 4
(4)
, Article FSO290. 10.4155/fsoa-2017-0109.
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Abstract
Since the discovery of antibiotics by Sir Alexander Fleming they have been used throughout medicine and play a vital role in combating microorganisms. However, with their vast use, development of resistance has become more prevalent and their use is currently under threat. Antibiotic resistance poses a global threat to human and animal health, with many bacterial species having developed some form of resistance and in some cases within a year of first exposure to antimicrobial agents. This review aims to examine some of the mechanisms behind resistance. Additionally, re-engineering organisms, re-sensitizing bacteria to antibiotics and gene-editing techniques such as the clustered regularly interspaced short palindromic repeats-Cas9 system are providing novel approaches to combat bacterial resistance. To that extent, we have reviewed some of these novel and innovative technologies.
Type: | Article |
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Title: | Antimicrobial resistance mechanisms and potential synthetic treatments |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.4155/fsoa-2017-0109 |
Publisher version: | https://doi.org/10.4155/fsoa-2017-0109 |
Language: | English |
Additional information: | © 2019 Future Science Group. This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit (http://creativecommons.org/licenses/by/4.0/). |
Keywords: | antibiotics, antimicrobial resistance, infectious agents, molecular biology, re-sensitizing, resistance mechanisms |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering |
URI: | https://discovery.ucl.ac.uk/id/eprint/10079373 |
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