UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Referral pathways for patients with NAFLD based on non-invasive fibrosis tests: diagnostic accuracy and cost analysis

Crossan, C; Majumdar, A; Srivastava, A; Thorburn, D; Rosenberg, W; Pinzani, M; Longworth, L; (2019) Referral pathways for patients with NAFLD based on non-invasive fibrosis tests: diagnostic accuracy and cost analysis. Liver International , 39 (11) pp. 2052-2060. 10.1111/liv.14198. Green open access

[thumbnail of Pinzani_Valenti_2019-Liver_International.pdf]
Preview
Text
Pinzani_Valenti_2019-Liver_International.pdf - Accepted Version

Download (974kB) | Preview

Abstract

Background/aims Non‐invasive fibrosis tests (NITs) can be used to triage non‐alcoholic fatty liver disease (NAFLD) patients at risk of advanced fibrosis (AF). We modeled and investigated the diagnostic accuracy and costs of a two‐tier NIT approach in primary care (PC) to inform secondary care referrals (SCRs). Methods A hypothetical cohort of 1,000 NAFLD patients with a 5% prevalence of AF was examined. Three referral strategies were modeled: refer all patients (Scenario 1), refer only patients with AF on NITs performed in PC (Scenario 2) and refer those with AF after biopsy (Scenario 3). Patients in Scenarios 1 and 2 would undergo sequential NITs if their initial NIT was indeterminate (FIB‐4 followed by Fibroscan®, ELF® or Fibrotest®). The outcomes considered were true/false positives and true/false negatives with associated mortality, complications, treatment and follow‐up depending on the care setting. Decision curve analysis was performed, which expressed the net benefit of different scenarios over a range of threshold probabilities (Pt). Results Sequential use of NITs provided lower SCR rates and greater cost savings compared to other scenarios over 5 years, with 90% of patients managed in PC and cost savings of over 40%. On decision curve analysis, FIB‐4 plus ELF was marginally superior to FIB‐4 plus Fibroscan at Pt≥8% (1/12.5 referrals). Below this Pt, FIB‐4 plus Fibroscan had greater net benefit. The net‐reduction in SCRs was similar for both sequential combinations. Conclusions The sequential use of NITs in PC is an effective way to rationalize SCRs and is associated with significant cost savings.

Type: Article
Title: Referral pathways for patients with NAFLD based on non-invasive fibrosis tests: diagnostic accuracy and cost analysis
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/liv.14198
Publisher version: https://doi.org/10.1111/liv.14198
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: ELF, FIB-4, Fibroscan, Fibrotest
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10079002
Downloads since deposit
132Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item