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Preschool Multiple-Breath Washout Testing An Official American Thoracic Society Technical Statement: Executive Summary

Robinson, PD; Latzin, P; Ramsey, KA; Stanojevic, S; Aurora, P; Davis, SD; Gappa, M; ... Ratjen, F; + view all (2018) Preschool Multiple-Breath Washout Testing An Official American Thoracic Society Technical Statement: Executive Summary. American Journal of Respiratory and Critical Care Medicine , 197 (5) pp. 557-572. 10.1164/rccm.201801-0074ST. Green open access

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Abstract

Background: Obstructive airway disease is non-uniformly distributed throughout the bronchial tree, although the heterogeneity to which this occurs can vary among conditions. The multiple breath washout (MBW) test offers important insights into pediatric lung disease, not available through spirometry or resistance measurements. The ERS/ATS inert gas washout (IGW) consensus statement led to emergence of validated commercial equipment for the age group 6 years and above; specific recommendations for preschool children were beyond the scope of the document. Subsequently the focus has shifted to MBW applications within preschool subjects (aged 2-6 years) where a “window of opportunity” exists for early diagnosis of obstructive lung disease and intervention. Methods: This preschool-specific technical standard document was developed by an international group of experts, with expertise in both custom-built and commercial MBW equipment. A comprehensive review of published evidence was performed. Results: Recommendations were devised across areas which place specific age-related demands on MBW systems. Citing evidence where available in the literature, recommendations are made regarding procedures that should be used to achieve robust MBW results in the preschool age range. The present work also highlights the important unanswered questions that need to be addressed in future work. Conclusions: Consensus recommendations are outlined to direct interested groups of manufacturers, researchers and clinicians in preschool device design, test performance and data analysis for the MBW technique

Type: Article
Title: Preschool Multiple-Breath Washout Testing An Official American Thoracic Society Technical Statement: Executive Summary
Open access status: An open access version is available from UCL Discovery
DOI: 10.1164/rccm.201801-0074ST
Publisher version: https://doi.org/10.1164/rccm.201801-0074ST
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: multiple-breath washout; lung clearance index; peripheral airway function; cystic fibrosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10079000
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