UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Exploring the enzymatic degradation of poly(glycerol adipate)

Swainson, SME; Taresco, V; Pearce, AK; Clapp, LH; Ager, B; McAllister, M; Bosquillon, C; (2019) Exploring the enzymatic degradation of poly(glycerol adipate). European Journal of Pharmaceutics and Biopharmaceutics , 142 pp. 377-386. 10.1016/j.ejpb.2019.07.015. Green open access

[img]
Preview
Text
Clapp_Exploring the enzymatic degradation of poly(glycerol adipate)_VoR.pdf - Published version

Download (1MB) | Preview

Abstract

Poly(glycerol adipate) (PGA) is a biodegradable, biocompatible, polymer with a great deal of potential in the field of drug delivery. Active drug molecules can be conjugated to the polymer backbone or encapsulated in self-assembled nanoparticles for targeted and systemic delivery. Here, a range of techniques have been used to characterise the enzymatic degradation of PGA extensively for the first time and to provide an indication of the way the polymer will behave and release drug payloads in vivo. Dynamic Light Scattering was used to monitor change in nanoparticle size, indicative of degradation. The release of a fluorescent dye, coupled to PGA, upon incubation with enzymes was measured over a 96 h period as a model of drug release from polymer drug conjugates. The changes to the chemical structure and molecular weight of PGA following enzyme exposure were characterised using FTIR, NMR and GPC. These techniques provided evidence of the biodegradability of PGA, its susceptibility to degradation by a range of enzymes commonly found in the human body and the polymer’s potential as a drug delivery platform.

Type: Article
Title: Exploring the enzymatic degradation of poly(glycerol adipate)
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ejpb.2019.07.015
Publisher version: https://doi.org/10.1016/j.ejpb.2019.07.015
Language: English
Additional information: © 2019 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Poly(glycerol adipate), Enzymatic degradation, Polyester, Biodegradable, Polymer modification, Breakdown
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/10078950
Downloads since deposit
18Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item