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Recent advances in gold nanoparticles for biomedical applications: from hybrid structures to multi-functionality

Jeong, H-H; Choi, E; Ellis, E; Lee, T-C; (2019) Recent advances in gold nanoparticles for biomedical applications: from hybrid structures to multi-functionality. Journal of Materials Chemistry B , 7 (22) pp. 3480-3496. 10.1039/c9tb00557a. Green open access

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Abstract

Gold nanoparticles (Au NPs) are arguably the most versatile nanomaterials reported to date. Recent advances in nanofabrication and chemical synthesis have expanded the scope of Au NPs from classical homogeneous nanospheres to a wide range of hybrid nanostructures with programmable size, shape and composition. Novel physiochemical properties can be achieved via design and engineering of the hybrid nanostructures. In this review we discuss the recent progress in the development of complex hybrid Au NPs and propose a classification framework based on three fundamental structural dimensions (length scale, complexity and symmetry) to aid categorising, comparing and designing various types of Au NPs. Their novel functions and potential for biomedical applications will also be discussed, featuring point-of-care diagnostics by advanced optical spectroscopy and assays, as well as minimally invasive surgeries and targeted drug delivery using multifunctional nano-robots.

Type: Article
Title: Recent advances in gold nanoparticles for biomedical applications: from hybrid structures to multi-functionality
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/c9tb00557a
Publisher version: http://dx.doi.org/10.1039/c9tb00557a
Language: English
Additional information: © The Royal Society of Chemistry 2019. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (http://creativecommons.org/licenses/by/3.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > MAPS Faculty Office > Institute for Materials Discovery
URI: https://discovery.ucl.ac.uk/id/eprint/10078904
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