Pontecorboli, G;
Biglino, G;
Milano, EG;
Sophocleous, F;
Biffi, B;
Dastidar, AG;
Schievano, S;
... Bucciarelli-Ducci, C; + view all
(2019)
Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy.
Computer Methods in Biomechanics and Biomedical Engineering
, 22
(14)
pp. 1103-1106.
10.1080/10255842.2019.1632836.
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Abstract
Takotsubo cardiomyopathy (TCM) is characterized by transient myocardial dysfunction, typically at the left ventricular (LV) apex. Its pathophysiology and recovery mechanisms remain unknown. We investigated LV morphology and deformation in n = 28 TCM patients. Patients with MRI within 5 days from admission ("early TCM") showed reduced LVEF and higher ventricular volumes, but no differences in ECG, global strains or myocardial oedema. Statistical shape modelling described LV size (Mode 1), apical sphericity (Mode 2) and height (Mode 3). Significant differences in Mode 1 suggest that "early TCM" LV remodeling is mainly influenced by a change in ventricular size rather than apical sphericity.
| Type: | Article |
|---|---|
| Title: | Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1080/10255842.2019.1632836 |
| Publisher version: | https://doi.org/10.1080/10255842.2019.1632836 |
| Language: | English |
| Additional information: | © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) |
| Keywords: | Takotsubo cardiomyopathy, cardiac magnetic resonance, computational modelling, myocardial deformation, statistical shape modelling |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Childrens Cardiovascular Disease |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10078598 |
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