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Multiparametric MRI for prostate cancer diagnosis: current status and future directions

Stabile, A; Giganti, F; Rosenkrantz, AB; Taneja, SS; Villeirs, G; Gill, IS; Allen, C; ... Kasivisvanathan, V; + view all (2019) Multiparametric MRI for prostate cancer diagnosis: current status and future directions. Nature Reviews Urology 10.1038/s41585-019-0212-4. (In press). Green open access

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Abstract

The current diagnostic pathway for prostate cancer has resulted in overdiagnosis and consequent overtreatment as well as underdiagnosis and missed diagnoses in many men. Multiparametric MRI (mpMRI) of the prostate has been identified as a test that could mitigate these diagnostic errors. The performance of mpMRI can vary depending on the population being studied, the execution of the MRI itself, the experience of the radiologist, whether additional biomarkers are considered and whether mpMRI-targeted biopsy is carried out alone or in addition to systematic biopsy. A number of challenges to implementation remain, such as ensuring high-quality execution and reporting of mpMRI and ensuring that this diagnostic pathway is cost-effective. Nevertheless, emerging clinical trial data support the adoption of this technology as part of the standard of care for the diagnosis of prostate cancer.

Type: Article
Title: Multiparametric MRI for prostate cancer diagnosis: current status and future directions
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41585-019-0212-4
Publisher version: https://doi.org/10.1038/s41585-019-0212-4
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/10078597
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