Barker, RA;
Farrell, K;
Guzman, NV;
He, X;
Lazic, SE;
Moore, S;
Morris, R;
... Winkler, C; + view all
(2019)
Designing stem-cell-based dopamine cell replacement trials for Parkinson's disease.
Nature Medicine
, 25
(7)
pp. 1045-1053.
10.1038/s41591-019-0507-2.
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Foltynie_AAM_Nature Medicine TRANSEURO and lesson learnt perspective FINAL (002).pdf - Accepted Version Download (1MB) | Preview |
Abstract
Clinical studies of Parkinson’s disease (PD) using a dopamine cell replacment strategy have been tried for more than 30 years. The outcomes following transplantation of human fetal ventral mesencephalic tissue (hfVM) have been variable, with some patients coming off their anti-PD treatment for many years and others not responding and/or developing significant side effects, including graft-induced dyskinesia. This led to a re-appraisal of the best way to do such trials, which resulted in a new European-Union-funded allograft trial with fetal dopamine cells across several centers in Europe. This new trial, TRANSEURO (NCT01898390), is an open-label study in which some individuals in a large observational cohort of patients with mild PD who were undergoing identical assessments were randomly selected to receive transplants of hfVM. The TRANSEURO trial is currently ongoing as researchers have completed both recruitment into a large multicenter observational study of younger onset early-stage PD and transplantation of hfVM in 11 patients. While completion of TRANSEURO is not expected until 2021, we feel that sharing the rationale for the design of TRANSEURO, along with the lessons we have learned along the way, can help inform researchers and facilitate planning of transplants of dopamine-producing cells derived from human pluripotent stem cells for future clinical trials.
| Type: | Article |
|---|---|
| Title: | Designing stem-cell-based dopamine cell replacement trials for Parkinson's disease |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41591-019-0507-2 |
| Publisher version: | https://doi.org/10.1038/s41591-019-0507-2 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Cognitive neuroscience, Diseases of the nervous system, Regeneration and repair in the nervous system, Stem cells in the nervous system, Clinical trial design |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10078560 |
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