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Characterization of a long noncoding RNA Pcdh17it as a novel marker for immature premyelinating oligodendrocytes

Kasuga, Y; Fudge, AD; Zhang, Y; Li, H; (2019) Characterization of a long noncoding RNA Pcdh17it as a novel marker for immature premyelinating oligodendrocytes. Glia , 67 (11) pp. 2166-2177. 10.1002/glia.23684. Green open access

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Abstract

Oligodendrocyte precursors (OPs) proliferate and differentiate into oligodendrocytes (OLs) during postnatal development and into adulthood in the central nervous system (CNS). Following the initiation of differentiation, OPs give rise to immature, premyelinating OLs, which undergo further differentiation and mature into myelin-forming OLs. We identified an immature OL-specific long noncoding RNA, named Pcdh17it. Through co-localization analysis and morphological characterization of OLs, we found that Pcdh17it is a specific marker for newly born immature OLs in the developing and adult forebrain of mice, and we used this new marker to analyze OL generation over the lifespan of mice. Pcdh17it is an effective tool for monitoring newly born OLs in adult brain, allowing detailed study of the dynamics of OP differentiation into OLs in the normal and pathological CNS.

Type: Article
Title: Characterization of a long noncoding RNA Pcdh17it as a novel marker for immature premyelinating oligodendrocytes
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/glia.23684
Publisher version: https://doi.org/10.1002/glia.23684
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Pcdh17it, immature oligodendrocyte, long noncoding RNA, oligodendrocyte, oligodendrocyte dynamics, premyelinating oligodendrocyte
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/10078534
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