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Phenotyping UK Electronic Health Records from 15 Million Individuals for Precision Medicine: He CALIBER Resource

Denaxas, S; Gonzalez-Izquierdo, A; Fitzpatrick, N; Direk, K; Hemingway, H; (2019) Phenotyping UK Electronic Health Records from 15 Million Individuals for Precision Medicine: He CALIBER Resource. In: Health Informatics Vision: From Data via Information to Knowledge. (pp. pp. 220-223). IOS Press: Athens, Greece. Green open access

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Abstract

Electronic health records (EHR) are increasingly being used for observational research at scale. In the UK, we have established the CALIBER research resource which utilizes national primary and hospital EHR data sources and enables researchers to create and validate longitudinal disease phenotypes at scale. In this work, we will describe the core components of the resource and provide results from three exemplar research studies on high-resolution epidemiology, disease risk prediction and subtype discovery which demonstrate both the opportunities and challenges of using EHR for research.

Type: Proceedings paper
Title: Phenotyping UK Electronic Health Records from 15 Million Individuals for Precision Medicine: He CALIBER Resource
Event: 17th International Conference on Informatics, Management and Technology in Healthcare
Location: Athens, Greece
Dates: 5-7 July 2019
ISBN-13: 9781614999867
Open access status: An open access version is available from UCL Discovery
DOI: 10.3233/SHTI190058
Publisher version: http://ebooks.iospress.nl/volumearticle/51720
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: electronic health records, phenotyping, data linkage, prognosis, biomedical informatics
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine > MRC Unit for Lifelong Hlth and Ageing
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Health Informatics > Clinical Epidemiology
URI: https://discovery.ucl.ac.uk/id/eprint/10078522
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