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Placental MRI and its application to fetal intervention

Aughwane, R; Ingram, E; Johnstone, ED; Salomon, LJ; David, AL; Melbourne, A; (2019) Placental MRI and its application to fetal intervention. Prenatal Diagnosis 10.1002/pd.5526. (In press). Green open access

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Abstract

OBJECTIVE: Magnetic Resonance Imaging (MRI) of placental invasion has been part of clinical practice for many years. The possibility of being better able to assess placental vascularization and function using MRI has multiple potential applications. This review summarises up-to-date research on placental function using different MRI modalities. METHOD: We discuss how combinations of these MRI techniques have much to contribute to fetal conditions amenable for therapy such as singletons at high risk for FGR; and monochorionic twin pregnancies for planning surgery and counselling for selective growth restriction and transfusion conditions. RESULTS: The whole placenta can easily be visualized on MRI, with a clear boundary against the amniotic fluid, and a less clear placental-uterine boundary. Contrasts such as Diffusion Weighted Imaging, Relaxometry, Blood Oxygenation Level Dependent MRI and flow and metabolite measurement by Dynamic Contrast Enhanced MRI, Arterial Spin Labeling or spectroscopic techniques are contributing to our wider understanding of placental function. CONCLUSION: The future of placental MRI is exciting, with the increasing availability of multiple contrasts and new models that will boost the capability of MRI to measure oxygen saturation and placental exchange, enabling examination of placental function in complicated pregnancies.

Type: Article
Title: Placental MRI and its application to fetal intervention
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/pd.5526
Publisher version: https://doi.org/10.1002/pd.5526
Language: English
Additional information: Copyright © 2019 The Authors. Prenatal Diagnosis published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/10078414
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