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Using optically-pumped magnetometers to measure magnetoencephalographic signals in the human cerebellum

Lin, C-H; Tierney, TM; Holmes, N; Boto, E; Leggett, J; Bestmann, S; Bowtell, R; ... Miall, RC; + view all (2019) Using optically-pumped magnetometers to measure magnetoencephalographic signals in the human cerebellum. The Journal of Physiology , 597 (16) pp. 4309-4324. 10.1113/JP277899. Green open access

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Abstract

We test the feasibility of an optically pumped magnetometer‐based magnetoencephalographic (OP‐MEG) system for the measurement of human cerebellar activity. This is to our knowledge the first study investigating the human cerebellar electrophysiology using optically pumped magnetometers. As a proof of principle, we use an air‐puff stimulus to the eyeball in order to elicit cerebellar activity that is well characterized in non‐human models. In three subjects, we observe an evoked component at approx. 50 ms post‐stimulus, followed by a second component at approx. 85–115 ms post‐stimulus. Source inversion localizes both components in the cerebellum, while control experiments exclude potential sources elsewhere. We also assess the induced oscillations, with time‐frequency decompositions, and identify additional sources in the occipital lobe, a region expected to be active in our paradigm, and in the neck muscles. Neither of these contributes to the stimulus‐evoked responses at 50–115 ms. We conclude that OP‐MEG technology offers a promising way to advance the understanding of the information processing mechanisms in the human cerebellum.

Type: Article
Title: Using optically-pumped magnetometers to measure magnetoencephalographic signals in the human cerebellum
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1113/JP277899
Publisher version: https://doi.org/10.1113/JP277899
Language: English
Additional information: © 2019 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/).
Keywords: optically pumped magnetometer, magnetoencephalography, cerebellum, eyeblink conditioning
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10078326
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