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Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials: JACC Scientific Expert Panel

Ibanez, B; Aletras, AH; Arai, AE; Arheden, H; Bax, J; Berry, C; Bucciarelli-Ducci, C; ... Fuster, V; + view all (2019) Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials: JACC Scientific Expert Panel. Journal of the American College of Cardiology , 74 (2) pp. 238-256. 10.1016/j.jacc.2019.05.024. Green open access

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Abstract

After a reperfused myocardial infarction (MI), dynamic tissue changes occur (edema, inflammation, microvascular obstruction, hemorrhage, cardiomyocyte necrosis, and ultimately replacement by fibrosis). The extension and magnitude of these changes contribute to long-term prognosis after MI. Cardiac magnetic resonance (CMR) is the gold-standard technique for noninvasive myocardial tissue characterization. CMR is also the preferred methodology for the identification of potential benefits associated with new cardioprotective strategies both in experimental and clinical trials. However, there is a wide heterogeneity in CMR methodologies used in experimental and clinical trials, including time of post-MI scan, acquisition protocols, and, more importantly, selection of endpoints. There is a need for standardization of these methodologies to improve the translation into a real clinical benefit. The main objective of this scientific expert panel consensus document is to provide recommendations for CMR endpoint selection in experimental and clinical trials based on pathophysiology and its association with hard outcomes.

Type: Article
Title: Cardiac MRI Endpoints in Myocardial Infarction Experimental and Clinical Trials: JACC Scientific Expert Panel
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jacc.2019.05.024
Publisher version: https://doi.org/10.1016/j.jacc.2019.05.024
Language: English
Additional information: © 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an Open Access article under the CC BY-NC-ND License (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: STEMI, area at risk, clinical trial, edema, endpoint, infarct size, magnetic resonance imaging, myocardial infarction
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/10078159
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