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EU/US/CTAD Task Force: Lessons Learned from Recent and Current Alzheimer's Prevention Trials

Aisen, P; Touchon, J; Amariglio, R; Andrieu, S; Bateman, R; Breitner, J; Donohue, M; ... Vanessa, Z; + view all (2017) EU/US/CTAD Task Force: Lessons Learned from Recent and Current Alzheimer's Prevention Trials. The Journal of Prevention of Alzheimer's Disease , 4 (2) pp. 116-124. 10.14283/jpad.2017.13. Green open access

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Abstract

At a meeting of the EU/US/Clinical Trials in Alzheimer’s Disease (CTAD) Task Force in December 2016, an international group of investigators from industry, academia, and regulatory agencies reviewed lessons learned from ongoing and planned prevention trials, which will help guide future clinical trials of AD treatments, particularly in the pre-clinical space. The Task Force discussed challenges that need to be addressed across all aspects of clinical trials, calling for innovation in recruitment and retention, infrastructure development, and the selection of outcome measures. While cognitive change provides a marker of disease progression across the disease continuum, there remains a need to identify the optimal assessment tools that provide clinically meaningful endpoints. Patient- and informant-reported assessments of cognition and function may be useful but present additional challenges. Imaging and other biomarkers are also essential to maximize the efficiency of and the information learned from clinical trials.

Type: Article
Title: EU/US/CTAD Task Force: Lessons Learned from Recent and Current Alzheimer's Prevention Trials
Open access status: An open access version is available from UCL Discovery
DOI: 10.14283/jpad.2017.13
Publisher version: https://doi.org/10.14283/jpad.2017.13
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Alzheimer’s disease; clinical trials; secondary prevention trials; cognitive outcome measures; cognitive composites; patient-reported outcome measures; informant-reported outcome measures; molecular imaging; mild behavioral impairment
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10078031
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