UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Minimal coarse-grained models for molecular self-organisation in biology

Hafner, AE; Krausser, J; Šarić, A; (2019) Minimal coarse-grained models for molecular self-organisation in biology. Current Opinion in Structural Biology , 58 pp. 43-52. 10.1016/j.sbi.2019.05.018. Green open access

[img]
Preview
Text
review_manuscript_ucl.pdf - Accepted version

Download (8MB) | Preview

Abstract

The molecular machinery of life is largely created via self-organisation of individual molecules into functional assemblies. Minimal coarse-grained models, in which a whole macromolecule is represented by a small number of particles, can be of great value in identifying the main driving forces behind self-organisation in cell biology. Such models can incorporate data from both molecular and continuum scales, and their results can be directly compared to experiments. Here we review the state of the art of models for studying the formation and biological function of macromolecular assemblies in living organisms. We outline the key ingredients of each model and their main findings. We illustrate the contribution of this class of simulations to identifying the physical mechanisms behind life and diseases, and discuss their future developments.

Type: Article
Title: Minimal coarse-grained models for molecular self-organisation in biology
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.sbi.2019.05.018
Publisher version: https://doi.org/10.1016/j.sbi.2019.05.018
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy
URI: https://discovery.ucl.ac.uk/id/eprint/10077960
Downloads since deposit
24Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item