UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Fatigue in multiple sclerosis: The role of thalamus

Capone, F; Collorone, S; Cortese, R; Di Lazzaro, V; Moccia, M; (2019) Fatigue in multiple sclerosis: The role of thalamus. Multiple Sclerosis Journal 10.1177/1352458519851247. (In press). Green open access

[img]
Preview
Text
Collorone_Fatigue in multiple sclerosis. The role of thalamus_AAM.pdf - Accepted version

Download (1MB) | Preview

Abstract

Fatigue is very common in multiple sclerosis (MS) and is often considered as its most disabling symptom. Over the last 20 years, an increasing number of studies have evaluated the pathogenetic bases of MS-related fatigue. Converging evidence from neurophysiology and neuroimaging research suggests that a dysfunction in a cortico-subcortical pathway, centered on thalamus, is involved in the pathogenesis of fatigue. However, type and significance of such dysfunction remain unknown, and some studies reported an increase in the activity and connectivity within the thalamic network, whereas others suggested its reduction. Hereby, we review the results of neuroimaging studies supporting the different hypotheses about the role of thalamic network in the pathophysiology of MS-related fatigue and discuss limitations and shortcomings of available data, highlighting the key challenges in the field and the directions for future research.

Type: Article
Title: Fatigue in multiple sclerosis: The role of thalamus
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/1352458519851247
Publisher version: https://doi.org/10.1177%2F1352458519851247
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Fatigue, MRI, multiple sclerosis, neuroimaging, thalamus
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/10077679
Downloads since deposit
73Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item