Robbins, HA;
Callister, M;
Sasieni, P;
Quaife, SL;
Cheung, LC;
Brennan, P;
Katki, HA;
... Johansson, M; + view all
(2019)
Benefits and harms in the National Lung Screening Trial: expected outcomes with a modern management protocol.
The Lancet Respiratory Medicine
, 7
(8)
pp. 655-656.
10.1016/s2213-2600(19)30136-5.
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Abstract
Lung cancer screening is receiving increasing attention worldwide, both in the medical community and the general public. Multiple randomised trials — including the US National Lung Screening Trial (NLST), the Multicentric Italian Lung Detection trial, and preliminary results from the Dutch-Belgian NELSON trial — have provided definitive evidence that low-dose CT screening can reduce lung cancer mortality. However, any screening programme is associated with both benefits and harms, and accurately communicating these to patients and the general public is a complex challenge. Given the complexity of the debate, it is difficult for primary care providers to understand and explain the benefits and harms of screening to their patients. Multiple graphical tools have been developed and published to aid this conversation, each based on the NLST, and other bespoke graphics have been used in pilot studies. However, some of the published graphics can be misleading, and all represent outcomes based on the NLST protocol, which is now nearly 20 years old. We engaged an international group of lung screening experts with the goal of assembling and providing accurate and balanced information on the benefits and harms of NLST-like low-dose CT screening. We compiled these results into an infographic, along with a full-page version with explanatory text. Our new infographic represents a contemporary interpretation of the findings of NLST using a modern protocol.
| Type: | Article |
|---|---|
| Title: | Benefits and harms in the National Lung Screening Trial: expected outcomes with a modern management protocol |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/s2213-2600(19)30136-5 |
| Publisher version: | https://doi.org/10.1016/S2213-2600(19)30136-5 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Behavioural Science and Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10077620 |
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