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Oncolytic Measles Virotherapy and Opposition to Measles Vaccination

Russell, SJ; Babovic-Vuksanovic, D; Bexon, A; Cattaneo, R; Dingli, D; Dispenzieri, A; Deyle, DR; ... Peng, K-W; + view all (2019) Oncolytic Measles Virotherapy and Opposition to Measles Vaccination. Mayo Clinic Proceedings 10.1016/j.mayocp.2019.05.006. (In press). Green open access

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Abstract

Recent measles epidemics in US and European cities where vaccination coverage has declined are providing a harsh reminder for the need to maintain protective levels of immunity across the entire population. Vaccine uptake rates have been declining in large part because of public misinformation regarding a possible association between measles vaccination and autism for which there is no scientific basis. The purpose of this article is to address a new misinformed antivaccination argument-that measles immunity is undesirable because measles virus is protective against cancer. Having worked for many years to develop engineered measles viruses as anticancer therapies, we have concluded (1) that measles is not protective against cancer and (2) that its potential utility as a cancer therapy will be enhanced, not diminished, by prior vaccination.

Type: Article
Title: Oncolytic Measles Virotherapy and Opposition to Measles Vaccination
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.mayocp.2019.05.006
Publisher version: https://doi.org/10.1016/j.mayocp.2019.05.006
Language: English
Additional information: © 2019 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license http://creativecommons.org/ licenses/by-nc-nd/4.0/).
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: https://discovery.ucl.ac.uk/id/eprint/10077601
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