UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Stepped wedge trials with continuous recruitment require new ways of thinking

Hooper, R; Copas, A; (2019) Stepped wedge trials with continuous recruitment require new ways of thinking. Journal of Clinical Epidemiology , 116 pp. 161-166. 10.1016/j.jclinepi.2019.05.037. Green open access

[thumbnail of Copas_1-s2.0-S0895435619304974-main.pdf]
Preview
Text
Copas_1-s2.0-S0895435619304974-main.pdf - Published Version

Download (244kB) | Preview

Abstract

Objectives: There is substantial variation in the design of stepped wedge trials. Many recruit participants continuously over time, although the methodological literature has tended not to differentiate closely between continuous recruitment and discrete sampling. We argue for a deeper understanding of the special features of stepped wedge trials with continuous recruitment. / Study Design and Setting: This is a commentary and informal review. / Results: We discuss the scheduling of recruitment and implementation in continuous time and how contamination might be avoided. We also offer some suggestions on reporting and terminology for stepped wedge trials with continuous recruitment and comment on issues for analysis. / Conclusion: Repeated cross-section and continuous recruitment stepped wedge trials are not the same thing. More work is needed to develop the theory and practice of stepped wedge designs with continuous recruitment. Thoughtful approaches to design and clarity of reporting are vital.

Type: Article
Title: Stepped wedge trials with continuous recruitment require new ways of thinking
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jclinepi.2019.05.037
Publisher version: https://doi.org/10.1016/j.jclinepi.2019.05.037
Language: English
Additional information: Copyright © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Stepped wedge, Cluster randomized trials, Continuous recruitment, Contamination, Interrupted time series
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/10077500
Downloads since deposit
46Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item