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Mixing Time in Intermediate-Sized Orbitally Shaken Reactors with Small Orbital Diameters

Li, Y; Ducci, A; Micheletti, M; (2019) Mixing Time in Intermediate-Sized Orbitally Shaken Reactors with Small Orbital Diameters. Chemical Engineering & Technology , 42 (8) pp. 1611-1617. 10.1002/ceat.201900063. Green open access

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Abstract

Orbitally shaken reactors (OSR) are widely used in bioprocess development; however, a scaling law between large reactors, usually shaken in incubators at an orbital diameter of d o = 1.5–5 cm, and microwell plates, shaken in benchtop thermomixers at d o = 3 mm, is still missing. Here, the mixing time was measured in two reactors with the same volume but either cylindrical or square geometry for d o = 3 mm. For such a small d o, the acceleration mode to reach the final speed in the cylinder was found to greatly affect the free surface oscillations and thus the mixing time. The stepwise mode resulted in mixing times approximately six times smaller than in the direct mode. The natural frequency of the reactor, which is independent of d o, was found to be an effective scaling parameter for systems with small d o.

Type: Article
Title: Mixing Time in Intermediate-Sized Orbitally Shaken Reactors with Small Orbital Diameters
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/ceat.201900063
Publisher version: https://doi.org/10.1002/ceat.201900063
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Dual indicator method; Microwell plates; Mixing time; Orbitally shaken; Scaling.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Biochemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10077490
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